Notre-Dame de Paris, un roman historique, publie en 1831. Le titre fait reference a la cathedrale de Paris, Notre-Dame, qui est un des lieux principaux de l'intrigue du roman. Le roman historique tel que le conceit Hugo comporte egalement une part de reflexion philosophique et morale.

Author ,
Isbn 5521004904
Genre Fiction
Year
Pages
Language English
File format PDF

Witchcraft and magical beliefs have captivated historians and artists for millennia, and stimulated an extraordinary amount of research among scholars in a wide range of disciplines. This new collection, from the editor of the highly acclaimed 1992 set, Articles on Witchcraft, Magic, and Demonology, extends the earlier volumes by bringing together the most important articles of the past twenty years and covering the profound changes in scholarly perspective over the past two decades. Featuring thematically organized papers from a broad spectrum of publications, the volumes in this set encompass the key issues and approaches to witchcraft research in fields such as gender studies, anthropology, sociology, literature, history, psychology, and law. This new collection provides students and researchers with an invaluable resource, comprising the most important and influential discussions on this topic. A useful introductory essay written by the editor precedes each volume.

Author Brian P. Levack
Isbn 1136539115
Genre History
Year 2013-08-06
Pages 350
Language English
File format PDF

Nos convictions et nos rêves nous appartiennent-ils ? Si nous pouvions bâtir un monde nouveau, le ferions-nous vraiment ?Fin des années quatre-vingt-dix. Juste après avoir reçu une lettre de sa grand-mère, pourtant morte depuis des mois, Charles Dupuy prend une décision radicale. L’acteur au sommet quitte l’effervescence de Paris pour une petite ville du nord de la France. Celle de son enfance. Ses amis, sa tante, les paysages et la lumière lui ont tant manqué. C’est la vérité, mais ce n’est pas tout. Il ne pense plus qu’à remonter à la source d’un pouvoir immense. Qu’à s’immerger dans des secrets et des histoires aussi magnifiques qu’atroces. Vous aimez que la littérature fantastique réinvente les mythes et les légendes ? Qu’elle réimagine ses figures tutélaires (sorcières, devineresse, Élu...) et ses thèmes de prédilection ? Vous sentez qu’au fond de vous se love un monde extraordinaire ? Pour vous, la musique des années quatre-vingt-dix touche à la perfection ? Alors Blanc trou noir pourrait vous plaire !

Author Aurélien Lenaars
Isbn
Genre Fiction
Year 2021-10-13T00:00:00Z
Pages N.A
Language English
File format PDF

Roald Dahl's darkly funny masterpiece, The Witches, now available as a graphic novel from Eisner Award-winning artist Pénélope Bagieu! Witches are real, and they are very, very dangerous. They wear ordinary clothes and have ordinary jobs, living in ordinary towns all across the world -- and there's nothing they despise more than children. When an eight-year-old boy and his grandmother come face-to-face with the Grand High Witch herself, they may be the only ones who can stop the witches' latest plot to stamp out every last child in the country!This full-color graphic novel edition of Roald Dahl's The Witches, adapted and illustrated by Eisner Award winner Pénélope Bagieu, is the first-ever Dahl story to appear in this format. Graphic novel readers and Roald Dahl fans alike will relish this dynamic new take on a uniquely funny tale.

Author Roald Dahl
Isbn 1338677454
Genre Juvenile Fiction
Year 2020-09-01
Pages 304
Language English
File format PDF

The Siberian sturgeon, Acipenser baerii Brandt 1869 is the most widely farmed sturgeon species. Continuing from Volume 1, which focuses on the biology of the species, the present Volume 2 in turn examines farming aspects. It is divided into six parts, the first of which deals with reproduction and early ontogenesis, i.e. reproductive cycles, controlled reproduction, sperm cryoconservation, and weaning of larvae. The second covers the growing phase with a focus on food and feeding (management, fish meal replacement, potential endocrine disruptions, usefulness of prebiotics and immunostimulants, and nitrogen excretion). Production-related data are the focus of the third part and include: characteristics (countries, structures of production, evolution in production, economic features) of the gross production of the species (meat and caviar) worldwide, a method for assessing the quality of caviars, off-flavors management, and an example of production of fingerlings for restocking. Part four addresses selected long-term management issues: genetic variability of brood stocks, genome manipulation and sex control, and the advantages of hybrids. The next three chapters constitute the fifth part, which is devoted to health status (immunology and welfare). In closing, the absence of ecological risks of introducing the species in non-native waters is shown using two long-term documented examples (Russia and France). Three methodological chapters round out the volume, covering: in vitro incubation of ovarian follicles, a richly illustrated library of echographies and photos, and a detailed presentation of oxygen demand studies.

Author Patrick Williot,Guy Nonnotte,Mikhail Chebanov
Isbn 3319616765
Genre Science
Year 2018-04-09
Pages 590
Language English
File format PDF

Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer's disease, epilepsy, alcoholism, substance abuse and others are some of the most debilitating illnesses worldwide characterized by the complexity of causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures. Recent advances in neuroscience, genomic, genetic, proteomic and metabolomic knowledge and technologies have opened the way to searching biomarkers and endophenotypes, which may offer powerful and exciting opportunities to understand the etiology and the underlying pathophysiological mechanisms of neuropsychiatric disorders. The challenge now is to translate these advances into meaningful diagnostic and therapeutic advances. This book offers a broad synthesis of the current knowledge about diverse topics of the biomarker and endophenotype strategies in neuropsychiatry. The book is organized into four interconnected volumes: “Neuropsychological Endophenotypes and Biomarkers” (with overview of methodological issues of the biomarker and endophenotype approaches in neuropsychiatry and some technological advances), “Neuroanatomical and Neuroimaging Endophenotypes and Biomarkers”, “Metabolic and Peripheral Biomarkers” and “Molecular Genetic and Genomic Markers”. The contributors are internationally and nationally recognized researchers and experts from 16 countries. This four-volume handbook is intended for a broad spectrum of readers including neuroscientists, psychiatrists, neurologists, endocrinologists, pharmacologists, clinical psychologists, general practitioners, geriatricians, health care providers in the field of neurology and mental health interested in trends that have crystallized in the last decade, and trends that can be expected to further evolve in the coming years. It is hoped that this book will also be a useful resource for the teaching of psychiatry, neurology, psychology and mental health.

Author Michael Ritsner
Isbn 1402098383
Genre Medical
Year 2009-04-21
Pages 213
Language English
File format PDF

Since the publication of the first edition of Chemistry of Protein Conjugation and Cross-Linking in 1991, new cross-linking reagents, notably multifunctional cross-linkers, have been developed and synthesized. The completion of the human genome project has opened a new area for studying nucleic acid and protein interactions using nucleic acid cross-linking reagents, and advances have also been made in the area of biosensors and microarray biochips for the detection and analysis of genes, proteins, and carbohydrates. In addition, developments in physical techniques with unprecedented sensitivity and resolution have facilitated the analysis of cross-linked products. Updated to reflect the advances of the 21st century, this book offers: An overview of the chemical principles underlying the processes of cross-linking and conjugation A thorough list of cross-linking reagents published in the literature since the first edition, covering monofunctional, homobifunctional, heterobifunctional, multifunctional, and zero-length cross-linkers Reviews of the use of these reagents in studying protein tertiary structures, geometric arrangements of subunits within complex proteins and nucleic acids, near-neighbor analysis, protein-to-protein or ligand–receptor interactions, and conformational changes of biomolecules Discusses the application of immunoconjugation for immunoassays, immunotoxins for targeted therapy, microarray technology for analysis of various biomolecules, and solid state chemistry for immobilizations

Author Shan S. Wong,David M. Jameson
Isbn 1420007645
Genre Medical
Year 2011-10-10
Pages 622
Language English
File format PDF

Translated into twenty-two languages. Toby Lolness may be just one and a half millimeters tall, but he’s the most wanted person in his world -- the world of the great oak Tree. Toby’s father has made a groundbreaking discovery: the Tree itself is alive, lowing with vital energy, and there may even be a world beyond it. Greedy developers itch to exploit this forbidden knowledge, risking permanent damage to their natural world. But Toby’s father has refused to reveal his findings, causing the family to be exiled to the lower branches. Only Toby has managed to escape -- but for how long? And how can he bear to leave his parents to their terrible fate?

Author Timothée de Fombelle
Isbn 076365180X
Genre Juvenile Fiction
Year 2010-08-10
Pages 400
Language English
File format PDF

The advances in human genetics that have ocurred during the past 20 years have revolutionized our knowledge of the role played by inheritance in health and disase. It is clear that our DNA determines not only the emergence of catastrophic single-gene disorders, which affect millions of persons worldwide, but also interacts with environments to predispose individuals to cancer, allergy, hypertension, heart disease, diabetes, psychiatric disorders and even to some infectious diseases. Overall, the study of longevity and the demonstration of genes favouring a long lifespan suggest that such protective systems exist. In recent years, the study of genetic polymorphisms has made clear that some alleles have beneficial effects. These discoveries can substantially improve our understanding of the interactions between genetics and the environment, between pathogenetic mechanisms and new treatments.

Author V. Boulyjenkov,K. Berg,Y. Christen
Isbn 3642569471
Genre Medical
Year 2012-12-06
Pages 180
Language English
File format PDF

Volume 36 of "Progress in Drug Research" contains 5 articles and the various indexes which facilitate its use and establish the connec tion with the previous volumes. While all articles deal with some of the topical aspects of drug research, the contribution by Robert R. Ruffolo et al. on "Drug receptors and control of the cardiovas cular system: Recent advances" is indeed in its own right a mono graphic presentation of this important domain. The remaining four reviews provide an overview of the work in volved in the search for new and better medicines, with a focus on chemical, pharmacological, toxicological, biological, biochemical and molecular modeling studies. In the 31 years this series has existed, the Editor has enjoyed the help and advice of many colleagues. Readers, the authors of the in dividual articles, and, last but not least, the reviewers have all con tributed greatly to the success of PDR. Although many comments received have been favorable, it is nevertheless necessary to analyze and to reconsider the current position and the direction of such a series. So far, it has been the Editor's aim to help spread informa tion on the vast domain of drug research, and to provide the reader with a tool helping him or her to keep abreast of the latest develop ments and trends.

Author JUCKER
Isbn 3034871333
Genre Juvenile Nonfiction
Year 2013-03-07
Pages 606
Language English
File format PDF

From somewhat enigmatic beginnings 40 years ago, guanylate cyclase research has emerged to occupy a position of prominence in the study of signal transduction. Guanylate cyclase has several intriguing features, including existence in two major forms, membrane and soluble, each independently regulated by distinct mechanisms. The membrane form gives rise to a fascinating signal transduction story important to both peptide hormones and sensory neurons. This volume covers the evolution of the field, peptide hormone receptor work, membrane guanylate cycles, related retinal diseases, and the biochemistry and physiology of the soluble form. The 16 chapters are written by leaders in the field.

Author Rameshwar K. Sharma
Isbn 1461509270
Genre Science
Year 2012-12-06
Pages 190
Language English
File format PDF

The HDL Handbook: Biological Functions to Clinical Implications brings laboratory research in HDL from bench to bedside in this needed resource for researchers and clinicians studying cholesterol, lipids, epidemiology, biochemistry, molecular medicine, and pathophysiology of cardiovascular diseases. In addition, researchers and clinicians working with an aging population, corporate researchers, post-doctorates; medical students and graduate students will find this publication useful because the scope of coverage includes basic science, genetics, epidemiology, and treatment of HDL cholesterol as well as potential targets to modify HDL cholesterol. Comprehensive coverage of basic science, genetics, epidemiology and treatment Reputable content on latest advances in HDL cholesterol research Inclusive, worldwide content with country specific information In depth discussion of potential targets to modify HDL

Author Tsugikazu Komoda
Isbn 9780123821720
Genre Medical
Year 2010-09-06
Pages 296
Language English
File format PDF

Brood parasitism has become one of the most flourishing areas of research in evolutionary ecology and one of the best model systems for investigating coevolution. This subject has undergone remarkable advances during the last two decades, but has not been covered by any book in the 21st century. This book offers a comprehensive and up-to-date overview of the fascinating field of avian brood parasitism. The topics covered include conspecific brood parasitism; evolution and phylogenetic history of avian brood parasites; parasitic behaviour used by brood parasites; adaptations and counter-adaptations of brood parasites and their hosts at every stage of the breeding cycle (before laying, egg, chick and fledgling stages); factors affecting the evolution of host defences and parasitic attacks; the role of phenotypic plasticity in host defences; mechanisms driving egg recognition and rejection; evolution of nest sharing or nest killing by brood parasite chicks; begging behaviour in parasitized nests and food delivery by host adults; and recognition of conspecifics by juvenile brood parasites. This volume provides a comprehensive reference resource for readers and researchers with an interest in birds, behaviour and evolution, as well as a source of hypotheses and predictions for future investigations into this dynamic subject.

Author Manuel Soler
Isbn 3319731386
Genre Science
Year 2018-05-02
Pages 574
Language English
File format PDF

This book meets the long-awaited need for a comprehensive overview of the biological role of HDLs. Edited by one of the pioneers in HDL and cholesterol research, this monograph summarizes current knowledge on HDL turnover, regulation and physiology. Clearly structured, the various sections cover HDL structure, formation, secretion and removal, as well as plasma metabolic factors. The biological activities and clinical aspects are equally discussed, as is the impact of HDL on common diseases and their prevention.

Author Christopher J. Fielding
Isbn 9783527625185
Genre Science
Year 2008-11-21
Pages 553
Language English
File format PDF

Knowledge of cholesterol and its interaction with protein molecules is of fundamental importance in both animal and human biology. This book contains 22 chapters, dealing in depth with structural and functional aspects of the currently known and extremely diverse unrelated families of cholesterol-binding and cholesterol transport proteins. By drawing together this range of topics the Editor has attempted to correlate this broad field of study for the first time. Technical aspects are given considerable emphasis, particularly in relation cholesterol reporter molecules and to the isolation and study of membrane cholesterol- and sphingomyelin-rich "raft" domains. Cell biological, biochemical and clinical topics are included in this book, which serve to emphasize the acknowledged and important benefits to be gained from the study of cholesterol and cholesterol-binding proteins within the biomedical sciences and the involvement of cholesterol in several clinical disorders. It is hoped that by presenting this topic in this integrated manner that an appreciation of the fact that there is much more that needs to be taken into account, studied and understood than the widely discussed "bad and good cholesterol" associated, respectively, with the low- and high-density lipoproteins, LDL and HDL.

Author J. Robin Harris
Isbn 9789048186228
Genre Science
Year 2010-03-10
Pages 632
Language English
File format PDF

The enormous advances in nanomedicine and precision medicine in the past two decades necessitated this comprehensive reference, which can be relied upon by researchers, clinicians, pharmaceutical scientists, regulators, policymakers, and lawyers alike. This standalone, full-color resource broadly surveys innovative technologies and advances pertaining to nanomedicine and precision medicine. In addition, it addresses often-neglected yet crucial areas such as translational medicine, intellectual property law, ethics, policy, FDA regulatory issues, nano-nomenclature, and artificial nano-machines—all accomplished in a user-friendly, broad yet interconnected format. The book is essential reading for the novice and the expert alike in diverse fields such as medicine, law, pharmacy, genomics, biomedical sciences, ethics, and regulatory science. The book’s multidisciplinary approach will attract a global audience and serve as a valuable reference resource for industry, academia, and government.

Author Shaker A. Mousa,Raj Bawa,Gerald F. Audette
Isbn 1000043495
Genre Medical
Year 2020-01-06
Pages 600
Language English
File format PDF

Prostate cancer is the commonest male cancer with over 5 million survivors in US alone. Worldwide, the problem is staggering and has attracted significant attention by media, scientists and cancer experts. Significant research, discoveries, innovations and advances in treatment of this cancer have produced voluminous literature which is difficult to synthesize and assimilate by the medical community. Prostate Cancer: A Comprehensive Perspective is a comprehensive and definitive source which neatly resolves this problem. It covers relevant literature by leading experts in basic science, molecular biology, epidemiology, cancer prevention, cellular imaging, staging, treatment, targeted therapeutics and innovative technologies. Prostate Cancer: A Comprehensive Perspective, is a valuable and timely resource for urologists and oncologists.

Author Ashutosh Tewari
Isbn 1447128648
Genre Medical
Year 2013-04-05
Pages 1110
Language English
File format PDF

Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes provides an in-depth examination of the role of endothelium and endothelial dysfunction in normal vascular function, and in a broad spectrum of clinical syndromes, from atherosclerosis, to cognitive disturbances and eclampsia. The endothelium is a major participant in the pathophysiology of diseases, such as atherosclerosis, diabetes and hypertension, and these entities are responsible for the largest part of cardiovascular mortality and morbidly. Over the last decade major new discoveries and concepts involving the endothelium have come to light. This important reference collects this data in an easy to reference resource. Written by known experts, and covering all aspects of endothelial function in health and disease, this reference represents an assembly of recent knowledge that is essential to both basic investigators and clinicians. Provides a complete overview of endothelial function in health and diseases, along with an assessment of new information Includes coverage of groundbreaking areas, including the artificial LDL particle, the development of a new anti-erectile dysfunction agent, a vaccine for atherosclerosis, coronary calcification associated with red wine, and the interplay of endoplasmic reticulum/oxidative stress Explores the genetic features of endothelium and the interaction between basic knowledge and clinical syndromes

Author Protasio Lemos Da Luz,Peter Libby,Francisco Rafael Martins Laurindo,Antonio Carlos Palandri Chagas
Isbn 0128125519
Genre Medical
Year 2018-02-03
Pages 758
Language English
File format PDF

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here once again, outstanding and original reviews are presented. Cell Transformation by the E7 Oncoprotein of HPV Type 16: Interactions with Nuclear and Cytoplasmic Target Proteins Tumor Invasion: Role of Growth Factor-Induced Cell Motility Non-Enzymatic Interactions Between Proteinases and the Cell Surface: Novel Roles in Normal and Malignant Cell Physiology Molecular Pathogenesis of AIDS-Associated Kaposi's Sarcoma: Growth and Apoptosis Perspectives on Cancer Chemoprevention Research and Drug Development

Author ,
Isbn 9780080562599
Genre Science
Year 1999-11-16
Pages 345
Language English
File format PDF